Andy Lau is Wesley, investigating alien existence on this earth. He works outside of the MIB-influenced FBI operation, run by Shu Qi and Roy Cheung. They’re hot on the trail of the Blue-Blooded Alien (Rosamund Kwan). Two other aliens, the “Warlock Toxin Group,” are gunning for her as well — red maggoty swarming creatures that form into Mark Cheng and Almen Wong.
A mysterious woman, known as Madame M, kidnaps forty pre-teen girls and transports them to a remote island to train them as the most deadly assassins. CIA operative Jack Chen follows the case for 6 years with no leads, but when a series of assassinations begin to occur, Jack suspects that Madame M is back in business.